The Best Longevity Supplements Backed by Science (2025 Guide)
Interest in longevity supplements has grown rapidly in recent years. Many products claim to slow aging, improve healthspan, or reverse biological age, but only a few are supported by strong clinical evidence.
This guide reviews the most promising science-backed supplements for longevity in 2025, explains how they work, and highlights what to consider before adding them to your routine.
What Are Longevity Supplements?
Longevity supplements are compounds studied for their ability to extend lifespan, slow aging, or reduce the risk of age-related diseases. Unlike generic vitamins, these supplements target cellular processes such as inflammation, mitochondrial function, and DNA repair.
Top Science-Backed Longevity Supplements
1. Vitamin D3
- Role: Supports immune function, bone health, and reduces all-cause mortality.
- Evidence: Multiple large studies confirm vitamin D deficiency is linked with reduced lifespan.
2. Omega-3 Fatty Acids (EPA & DHA)
- Role: Improve cardiovascular health and reduce systemic inflammation.
- Evidence: Associated with lower risk of heart disease and improved longevity.
3. Magnesium
- Role: Regulates over 300 biochemical reactions, essential for muscle, nerve, and metabolic health.
- Evidence: Higher magnesium intake is linked to reduced risk of premature death.
4. Creatine
- Role: Enhances muscle strength, brain energy metabolism, and protects against neurodegeneration.
- Evidence: Emerging studies link creatine to improved healthy aging beyond athletic performance.
5. Curcumin
- Role: Anti-inflammatory and antioxidant compound found in turmeric.
- Evidence: Shown to reduce chronic inflammation, a driver of accelerated aging.
6. NAD+ Boosters (NMN, NR)
- Role: Support mitochondrial function and energy metabolism.
- Evidence: Promising early research suggests NAD+ precursors may slow aspects of biological aging, though human data remains limited.
7. Rapamycin & Metformin (Emerging Therapies)
- Note: These are prescription drugs under investigation as longevity interventions. Clinical trials are ongoing.
What Supplements Cannot Do
It is important to note that supplements are not a replacement for lifestyle foundations such as sleep, exercise, nutrition, and stress management. They are best seen as adjuncts to a healthy longevity strategy.
How to Combine Supplements With Lifestyle
Supplements can amplify longevity benefits when paired with proven daily habits:
- Prioritize consistent, high-quality sleep.
- Follow a nutrient-rich longevity diet.
- Exercise with a balance of strength and cardio training.
- Track health data to monitor progress.
Conclusion
While the supplement industry is full of bold claims, the compounds above are supported by credible evidence and ongoing research. By pairing the right supplements with smart lifestyle habits, you can actively work to reduce your biological age and extend your healthspan.
At Uara.ai, we help you track how supplements and lifestyle changes impact your health in real time, using biomarkers and wearable data.
Take control of your longevity today — start measuring and optimizing with Uara.ai.